Pyrrole disorder, pyrroluria or “Mauve Factor” was first identified in the 1950s by Dr Abram Hoffer. Some people have persistent elevated levels due to abnormal haemoglobin metabolism or synthesis. Elevated pyrroles have been linked with mood disorders such as bipolar disorder, anxiety and depression. Stress, nutritional deficiency, and heavy metals such as lead and mercury can significantly increase pyrrole levels.
Pyrrole disorder, pyrroluria or “Mauve Factor” was first identified in the 1950s by Dr Abram Hoffer, Dr Humphrey Osmond and Dr Carl Pfeiffer.Pyrroles are a by-product of haemoglobin synthesis. Most people have low levels of pyrroles at any given time, but some people have persistent elevated levels due to abnormal haemoglobin metabolism or synthesis.
Elevated pyrroles have been linked with mood disorders such as bipolar disorder, anxiety and depression. This condition affects up to 10 per cent of the population but is more common in people with psychological, learning or behavioural problems.
There is a genetic basis to this condition. For example, if one parent has pyrrole disorder, then there is a fifty per cent chance that it may be passed onto a child. However genes alone do not guarantee pyrroluria. Genes need to be switched on and off. Many factors are responsible for switching these genes on and off, including stress, nutritional deficiency, and heavy metals such as lead and mercury that significantly increase pyrrole levels.
A combination of anxiety and high copper on a hair mineral test increase the diagnostic possibility that someone is suffering from pyrroluria.
Pyrroles bind vitamin B6 and Zinc making them unavailable for use by the body. Biotin, magnesium and manganese are also affected.
Symptoms may therefore include:
Poor dream recall
White spots on nails
Sensitivity to noise and bright lights.
A urine “mauve factor” test is the “gold standard’ used to diagnose pyrroluria. Hair mineral analysis is a good screening test that may show high copper and low zinc. Toxic metals such as mercury, lead and arsenic may also show up. Blood tests measuring copper, caeruloplasmin and zinc may also be useful.
If you do have pyrrole disorder, there are a number of things that we can do.
Supplements such as Vitamin B6, Magnesium, Manganese, Biotin, Vitamin C and essential fatty acids are all great ways to support the immune system and supplement any deficiencies caused by the pyrrole.
Additionally, digestive advice and treatment to repair intestinal permeability and improve nutrient absorption and detoxification of heavy metals such as lead and mercury can be of great assistance.
Lastly, since many of the symptoms relate to mood and energy, stress management is a really important thing to address as well since emotional stress is associated with increased pyrrole excretion.
Wishing you great health,
PS you are welcome to share this information with friends and family
About Dr Pete
Dr Peter Holsman is a qualified Medical Practitioner, Naturopath and Professional Speaker based in Melbourne. An expert in his field with over 30 years experience, he specialises in treating people with fatigue related illnesses including anxiety, stress, depression, chronic fatigue syndrome, digestive concerns, menopause, thyroid and adrenal hormone problems.
Quality rest is an important part of getting through the daily grind, yet nearly 50% of Australian adults experience two or more sleep-related problems, including difficulty falling asleep, staying asleep and daytime sleepiness. Find out how a sleep hygiene overhaul may help you secure a blissful date with your pillow...Read More
This blog explains how stress causes problems with your hormones, weight, bloating and digestion, ...Read More
Life will be different after lockdown....Read More
Gratitude is a great way to help you become more resilient and adaptable in times of stressRead More
Feeling out of control is a common emotion in these unsettling Covid-19 times. Find out what you can do to boost your energy, mood and resilience.Read More
How to boost your emotional resilience..Read More
Health, wealth and relationships can get complicated,....Read More
Anxiety is a common problem that often needs help....Read More
Find out about the power of language..Read More
How to boost your ability to manage difficult people or situations in this blog...Read More
Reduce anxiety, stress and depression by setting healthy boundaries. Find out how by reading this blog....Read More
This blog discusses how to make your home calming and tranquil. Read on ....Read More
This blog describes 5 simple ways of creating happiness....Read More
Welcome to a New Year of possibilities and an opportunuity to review your goals and resolutions. Read more...Read More
Stress is a big problem for many people. Click below to find out more.Read More
This blog post discusses how the weather can affect your mood. Click below to read more.Read More
This blog post discusses what you need to know about healthy work posture. Click below to read more.Read More
Yoga has been proven to have a really positive effect in reducing stress as well as improving fitness.Read More
Pyrrole disorder, pyrroluria or “Mauve Factor” was first identified in the 1950s by Dr Abram Hoffer. Some people have persistent elevated levels due to abnormal haemoglobin metabolism or synthesis. Elevated pyrroles have been linked with mood disorders such as bipolar disorder, anxiety and depression. Stress, nutritional deficiency, and heavy metals such as lead and mercury can significantly increase pyrrole levels.Read More
Anxiety and depression are common concerns for many of my patients and certainly affect millions of people in our country and around the world. Natural remedies can help address stress, anxiety and depression. They can also be used to help support people taking pharmaceutical antidepressants.Read More